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EnglishThe receptor tyrosine kinase Met and its ligand HGF/SF (hepatocyte growth factor/scatter factor) are essential in the signalling pathways required for embryogenesis and tissue regeneration. Aberrant signalling of this complex is also a feature of many tumours and appears to contribute to the growth, invasiveness and metastasis of both carcinomas and sarcomas. HGF/SF, like many other angiogenic growth factors, employs heparan sulphate as co-receptor. The role of this interaction has not been completely defined but appears to be physiologically relevant. Thus the presence of heparin increases the potency of HGF/SF in experiments with cells in culture leading to elevated downstream signalling effects and, although not vital for the Met-HGF/SF interaction, heparin or heparan sulphate is essential for the activity of certain isoforms of HGF/SF, such as NK1 and NK2. Here, we summarize the progress made in understanding the interaction between heparin and heparan sulphate and NK1, NK2 and HGF/SF and we discuss their role in HGF/SF-Met signalling.
Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors. / GHERARDI ERMANNO; KEMP LE; MULLOY B. - In: BIOCHEMICAL SOCIETY TRANSACTIONS. - ISSN 0300-5127. - STAMPA. - 34:3(2006), pp. 414-417.
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| Titolo: | Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors. |
| Autori: | |
| Data di pubblicazione: | 2006 |
| Rivista: | |
| Citazione: | Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors. / GHERARDI ERMANNO; KEMP LE; MULLOY B. - In: BIOCHEMICAL SOCIETY TRANSACTIONS. - ISSN 0300-5127. - STAMPA. - 34:3(2006), pp. 414-417. |
| Abstract: | The receptor tyrosine kinase Met and its ligand HGF/SF (hepatocyte growth factor/scatter factor) are essential in the signalling pathways required for embryogenesis and tissue regeneration. Aberrant signalling of this complex is also a feature of many tumours and appears to contribute to the growth, invasiveness and metastasis of both carcinomas and sarcomas. HGF/SF, like many other angiogenic growth factors, employs heparan sulphate as co-receptor. The role of this interaction has not been completely defined but appears to be physiologically relevant. Thus the presence of heparin increases the potency of HGF/SF in experiments with cells in culture leading to elevated downstream signalling effects and, although not vital for the Met-HGF/SF interaction, heparin or heparan sulphate is essential for the activity of certain isoforms of HGF/SF, such as NK1 and NK2. Here, we summarize the progress made in understanding the interaction between heparin and heparan sulphate and NK1, NK2 and HGF/SF and we discuss their role in HGF/SF-Met signalling. |
| Handle: | http://hdl.handle.net/11571/28619 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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