The interaction between the presence of severe myocardial ischemia and the anisotropic structure of the cardiac muscle is here investigated by means of numerical simulations of the anisotropic Bidomain and Monodomain models. The Bidomain model is a degenerate system of two parabolic reaction-diffusion equations that can be rewritten as a parabolic-elliptic system, while the Monodomain model consists of a single parabolic equation. Both models are coupled with a systems of ordinary differential equations related to the ionic currents flowing through the cellular membrane. The resulting fully coupled model includes intramural fiber rotation, orthotropic or axisymmetric anisotropy and homogeneous intrinsic membrane properties, modeled by an updated version of the Luo-Rudy membrane ionic model. Features of the cardiac excitation, recovery sequences and the distribution of the action potential duration elicited by a local stimulation are investigated in presence of severe subendocardial ischemia. Some epicardial markers correlated to the underlying subendocardial ischemic region are discussed.

Dynamical effects of myocardial ischemia in anisotropic cardiac models in three dimensions

COLLI FRANZONE, PIERO;PAVARINO, LUCA FRANCO;SCACCHI, SIMONE
2007

Abstract

The interaction between the presence of severe myocardial ischemia and the anisotropic structure of the cardiac muscle is here investigated by means of numerical simulations of the anisotropic Bidomain and Monodomain models. The Bidomain model is a degenerate system of two parabolic reaction-diffusion equations that can be rewritten as a parabolic-elliptic system, while the Monodomain model consists of a single parabolic equation. Both models are coupled with a systems of ordinary differential equations related to the ionic currents flowing through the cellular membrane. The resulting fully coupled model includes intramural fiber rotation, orthotropic or axisymmetric anisotropy and homogeneous intrinsic membrane properties, modeled by an updated version of the Luo-Rudy membrane ionic model. Features of the cardiac excitation, recovery sequences and the distribution of the action potential duration elicited by a local stimulation are investigated in presence of severe subendocardial ischemia. Some epicardial markers correlated to the underlying subendocardial ischemic region are discussed.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11571/32953
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