Adverse drug interactions in epilepsy

Adverse antiepileptic drug interactions may occur at pharmacokinetic and pharmacodynamic level. The most important adverse interactions in epilepsy therapy are pharmacokinetic and result from induction or inhibition of drug metabolizing enzymes. Pharmacodynamic interactions on the other hand take place directly at the sites of action, without any change in the concentration of the affected drug at receptor sites. In most situations. Adverse interactions can be prevented by avoiding unnecessary polytherapy, and by selecting comedications which are less likely to interact.