10B molecular compounds suitable for Boron Neutron Capture Therapy (BNCT) are tagged with a Gd(III) paramagnetic ion. The newly synthesized molecule, Gd-BPA, is investigated as contrast agent in Magnetic Resonance Imaging (MRI) with the final aim of mapping the boron distribution in tissues. Preliminary Nuclear Magnetic Resonance (NMR) measurements, which include 1H and 10B relaxometry in animal tissues, proton relaxivity of the paramagnetic Gd-BPA molecule in water and its absorption in tumoral living cells, are reported.
1H and 10B NMR and MRI investigation of boron- and gadolinium–boron compounds in boron neutron capture therapy
BONORA, MARCO;CORTI, MAURIZIO ENRICO;BORSA, FERDINANDO;BORTOLUSSI, SILVA;PROTTI, NICOLETTA;SANTORO, DAVIDE;STELLA, SABRINA;ALTIERI, SAVERIO;ZONTA, CECILIA;CLERICI, ANNA MARIA;CANSOLINO, LAURA;FERRARI, CINZIA;DIONIGI, PAOLO;PORTA, ALESSIO;ZANONI, GIUSEPPE;VIDARI, GIOVANNI
2011-01-01
Abstract
10B molecular compounds suitable for Boron Neutron Capture Therapy (BNCT) are tagged with a Gd(III) paramagnetic ion. The newly synthesized molecule, Gd-BPA, is investigated as contrast agent in Magnetic Resonance Imaging (MRI) with the final aim of mapping the boron distribution in tissues. Preliminary Nuclear Magnetic Resonance (NMR) measurements, which include 1H and 10B relaxometry in animal tissues, proton relaxivity of the paramagnetic Gd-BPA molecule in water and its absorption in tumoral living cells, are reported.File in questo prodotto:
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