Articular cartilage is a hypocellular, avascular, alymphatic tissue with a dense collagen and proteoglycan matrix that provides a low-friction and highly durable wear-resistant surface1 to both shear and compressive stress.Normal maintenance of articular cartilage results from the balance between anabolic and catabolic activity. Resident chondrocytes control the extracellular matrix turnover—collagen and proteoglycans synthesis and degradation—from the tidemark to the tangential zone of the cartilage. However, little is known about the physiological processes regulating cellular turnover and cartilage homeostasis, mainly because of the large number of factors involved (mechanical load, cell density, matrix composition, growth factors, cytokines, injury, and aging) and the complexity of their interactions.
Effects of electrical physical stimuli on articular cartilage
BENAZZO, FRANCESCO;
2007-01-01
Abstract
Articular cartilage is a hypocellular, avascular, alymphatic tissue with a dense collagen and proteoglycan matrix that provides a low-friction and highly durable wear-resistant surface1 to both shear and compressive stress.Normal maintenance of articular cartilage results from the balance between anabolic and catabolic activity. Resident chondrocytes control the extracellular matrix turnover—collagen and proteoglycans synthesis and degradation—from the tidemark to the tangential zone of the cartilage. However, little is known about the physiological processes regulating cellular turnover and cartilage homeostasis, mainly because of the large number of factors involved (mechanical load, cell density, matrix composition, growth factors, cytokines, injury, and aging) and the complexity of their interactions.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.