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EnglishWe investigated the proteinase inhibitory activity of MR 889, a thiolactic acid derivative. It is able to in vitro inhibit at low concentration (10(-5),10(-6)M) the activity of porcine pancreatic elastase, human neutrophil elastase and bovine chymotrypsin. In addition, MR 889 is able to inhibit the residual activity of alpha 2-macroglobulin-trapped human neutrophil elastase, paralleling the efficacy of phenylmethylsufonylfluoride. Finally, MR 889 has been shown to in vitro reduce the burden of elastase- and chymotrypsin-like activity found in sputum sol-phases of patients admitted for chronic bronchitis exacerbation.
Studies of MR 889, a new synthetic proteinase inhibitor. / M. Luisetti;P. D. Piccioni;M. Donnini;V. Peona;E. Pozzi;C. Grassi. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - STAMPA. - 165(1989), pp. 568-573.
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| Titolo: | Studies of MR 889, a new synthetic proteinase inhibitor. |
| Autori: | |
| Data di pubblicazione: | 1989 |
| Rivista: | |
| Citazione: | Studies of MR 889, a new synthetic proteinase inhibitor. / M. Luisetti;P. D. Piccioni;M. Donnini;V. Peona;E. Pozzi;C. Grassi. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - STAMPA. - 165(1989), pp. 568-573. |
| Abstract: | We investigated the proteinase inhibitory activity of MR 889, a thiolactic acid derivative. It is able to in vitro inhibit at low concentration (10(-5),10(-6)M) the activity of porcine pancreatic elastase, human neutrophil elastase and bovine chymotrypsin. In addition, MR 889 is able to inhibit the residual activity of alpha 2-macroglobulin-trapped human neutrophil elastase, paralleling the efficacy of phenylmethylsufonylfluoride. Finally, MR 889 has been shown to in vitro reduce the burden of elastase- and chymotrypsin-like activity found in sputum sol-phases of patients admitted for chronic bronchitis exacerbation. |
| Handle: | http://hdl.handle.net/11571/357085 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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