In this study, we present a full thermal characterization of antidepressant paroxetine and summarize the results for another drug which treats depression: GW597599B. The main aim is to analyze how the thermodynamic and structural properties of these compounds are modified when the two drugs are mixed in the solid state. We begin by putting into evidence how dehydration and melting concur in shaping the calorimetric curves of paroxetine under different experimental conditions. Equipped with this knowledge, we are able to interpret the thermal response of the physical mixtures paroxetine:GW597599B, in terms of partial eutectic formation and simple superposition of contribution from the two compounds.
Compatibility of paroxetine hydrochloride and GW597599B. A physico-chemical approach
BRUNI, GIOVANNA;BERBENNI, VITTORIO;MILANESE, CHIARA;MARINI, AMEDEO
2012-01-01
Abstract
In this study, we present a full thermal characterization of antidepressant paroxetine and summarize the results for another drug which treats depression: GW597599B. The main aim is to analyze how the thermodynamic and structural properties of these compounds are modified when the two drugs are mixed in the solid state. We begin by putting into evidence how dehydration and melting concur in shaping the calorimetric curves of paroxetine under different experimental conditions. Equipped with this knowledge, we are able to interpret the thermal response of the physical mixtures paroxetine:GW597599B, in terms of partial eutectic formation and simple superposition of contribution from the two compounds.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
