Four Clostridium perfringens phosphorylases were subcloned, overexpressed and analyzed for their substrate specificity. DeoD(1) and PunA could use a variety of purine substrates, including an antiviral drug 2',3'-dideoxyinosine (ddI). In one-pot synthesis using Clostridium phosphorylases, 2',3'-dideoxyuridine and hypoxanthine were converted to ddI at yield of about 30%.
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Titolo: | Nucleoside phosphorylases from clostridium perfringens in the synthesis of 2',3'-dideoxyinosine |
Autori: | |
Data di pubblicazione: | 2010 |
Rivista: | |
Abstract: | Four Clostridium perfringens phosphorylases were subcloned, overexpressed and analyzed for their substrate specificity. DeoD(1) and PunA could use a variety of purine substrates, including an antiviral drug 2',3'-dideoxyinosine (ddI). In one-pot synthesis using Clostridium phosphorylases, 2',3'-dideoxyuridine and hypoxanthine were converted to ddI at yield of about 30%. |
Handle: | http://hdl.handle.net/11571/369188 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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