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The aim of this study is to optimize targeted boron delivery to cancer cells and its tracking down to the cellular level. To this end, we describe the design and synthesis of novel nanovectors that double as targeted boron delivery agents and fluorescent imaging probes. Gold nanoparticles were coated with multilayers of polyelectrolytes functionalized with the fluorescent dye (FITC), boronophenylalanine and folic acid. In vitro confocal fluorescence microscopy demonstrated significant uptake of the nanoparticles in cancer cells that are known to overexpress folate receptors

Design, development and characterization of multi-functionalized gold nanoparticles for biodetection and targeted boron delivery in BNCT applications

FERRARI, CINZIA;CLERICI, ANNA MARIA;ZONTA, CECILIA;CANSOLINO, LAURA;BALLARINI, FRANCESCA;BORTOLUSSI, SILVA;STELLA, SABRINA;PROTTI, NICOLETTA;ALTIERI, SAVERIO
2011-01-01

Abstract

The aim of this study is to optimize targeted boron delivery to cancer cells and its tracking down to the cellular level. To this end, we describe the design and synthesis of novel nanovectors that double as targeted boron delivery agents and fluorescent imaging probes. Gold nanoparticles were coated with multilayers of polyelectrolytes functionalized with the fluorescent dye (FITC), boronophenylalanine and folic acid. In vitro confocal fluorescence microscopy demonstrated significant uptake of the nanoparticles in cancer cells that are known to overexpress folate receptors
2011
Biochemistry & Biophysics focuses on the structure and chemistry of biomolecules and covers all aspects of basic biochemistry/biophysics, including molecular structure, enzyme kinetics and protein-protein interaction; this category also contains cross-disciplinary resources focused on a specific class of biological molecules, e.g., nucleic acids, steroids, magnesium, growth factors, free radicals, bio-membranes, and peptides. Excluded are resources dealing with the application of biochemical techniques to specific topics listed elsewhere in CC/LS. Resources with a strong emphasis on the integration of biochemical pathways (such as signal transduction or molecular motors) at the cellular level are placed in the Cell & Developmental Biology category.
APPLIED RADIATION AND ISOTOPES
sì
WOS:000297426000018
2-s2.0-80055096361
Esperti anonimi
Inglese
Internazionale
STAMPA
69
12
1692
1697
6
21641810
BNCT; Functionalized gold nanoparticles; Targeted boron delivery; Folate receptor; Optical molecular imaging; Biocompatibility
13
info:eu-repo/semantics/article
262
Subhra, Mandal; Gerald J., Bakeine; Silke, Krol; Ferrari, Cinzia; Clerici, ANNA MARIA; Zonta, Cecilia; Cansolino, Laura; Ballarini, Francesca; Bortolu...espandi
1 Contributo su Rivista::1.1 Articolo in rivista
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1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/370866
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