To testtheefficacyofanew 10B-vectorcompound,theB/Gd/LDLadductsynthesisedatTorino University, in vivo irradiationsofmurinetumoursareinprogressattheTRIGAMarkIIreactorofthe Pavia University.AlocalisedB16melanomatumourisgeneratedinC57BL/6miceandsubsequently infused withtheadduct.Duringtheirradiation,themousewillbeputinashieldtoprotectthewhole body exceptthetumourintheback-neckarea.Tooptimisethetreatmentset-up,MCNPsimulations were performed.AverysimplifiedmousemodelwasbuiltusingMCNPgeometrycapabilities,aswellas the geometryoftheshieldmadeof99% 10B enrichedboricacid.Aholeintheshieldisforeseenin correspondenceoftheback-neckregion.Manyconfigurationsoftheshieldweretestedintermsof neutronflux,dosedistributionandmeaninducedactivityinthetumourregionandintheradio- sensitiveorgansofthemouse.Inthefinalset-up,uptofivemicecanbetreatedsimultaneouslyinthe reactorthermalcolumnandtheneutronfluenceinthetumourregionfor10minofirradiationisof about 51012 cm2.
Dose estimation in B16 tumour bearing mice for future irradiation in the thermal column of the TRIGA reactor after B/Gd/LDL adduct infusion.
PROTTI, NICOLETTA;BALLARINI, FRANCESCA;BORTOLUSSI, SILVA;STELLA, SABRINA;ALTIERI, SAVERIO
2011-01-01
Abstract
To testtheefficacyofanew 10B-vectorcompound,theB/Gd/LDLadductsynthesisedatTorino University, in vivo irradiationsofmurinetumoursareinprogressattheTRIGAMarkIIreactorofthe Pavia University.AlocalisedB16melanomatumourisgeneratedinC57BL/6miceandsubsequently infused withtheadduct.Duringtheirradiation,themousewillbeputinashieldtoprotectthewhole body exceptthetumourintheback-neckarea.Tooptimisethetreatmentset-up,MCNPsimulations were performed.AverysimplifiedmousemodelwasbuiltusingMCNPgeometrycapabilities,aswellas the geometryoftheshieldmadeof99% 10B enrichedboricacid.Aholeintheshieldisforeseenin correspondenceoftheback-neckregion.Manyconfigurationsoftheshieldweretestedintermsof neutronflux,dosedistributionandmeaninducedactivityinthetumourregionandintheradio- sensitiveorgansofthemouse.Inthefinalset-up,uptofivemicecanbetreatedsimultaneouslyinthe reactorthermalcolumnandtheneutronfluenceinthetumourregionfor10minofirradiationisof about 51012 cm2.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
