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To testtheefficacyofanew 10B-vectorcompound,theB/Gd/LDLadductsynthesisedatTorino University, in vivo irradiationsofmurinetumoursareinprogressattheTRIGAMarkIIreactorofthe Pavia University.AlocalisedB16melanomatumourisgeneratedinC57BL/6miceandsubsequently infused withtheadduct.Duringtheirradiation,themousewillbeputinashieldtoprotectthewhole body exceptthetumourintheback-neckarea.Tooptimisethetreatmentset-up,MCNPsimulations were performed.AverysimplifiedmousemodelwasbuiltusingMCNPgeometrycapabilities,aswellas the geometryoftheshieldmadeof99% 10B enrichedboricacid.Aholeintheshieldisforeseenin correspondenceoftheback-neckregion.Manyconfigurationsoftheshieldweretestedintermsof neutronflux,dosedistributionandmeaninducedactivityinthetumourregionandintheradio- sensitiveorgansofthemouse.Inthefinalset-up,uptofivemicecanbetreatedsimultaneouslyinthe reactorthermalcolumnandtheneutronfluenceinthetumourregionfor10minofirradiationisof about 51012 cm2.

Dose estimation in B16 tumour bearing mice for future irradiation in the thermal column of the TRIGA reactor after B/Gd/LDL adduct infusion.

PROTTI, NICOLETTA;BALLARINI, FRANCESCA;BORTOLUSSI, SILVA;STELLA, SABRINA;ALTIERI, SAVERIO
2011-01-01

Abstract

To testtheefficacyofanew 10B-vectorcompound,theB/Gd/LDLadductsynthesisedatTorino University, in vivo irradiationsofmurinetumoursareinprogressattheTRIGAMarkIIreactorofthe Pavia University.AlocalisedB16melanomatumourisgeneratedinC57BL/6miceandsubsequently infused withtheadduct.Duringtheirradiation,themousewillbeputinashieldtoprotectthewhole body exceptthetumourintheback-neckarea.Tooptimisethetreatmentset-up,MCNPsimulations were performed.AverysimplifiedmousemodelwasbuiltusingMCNPgeometrycapabilities,aswellas the geometryoftheshieldmadeof99% 10B enrichedboricacid.Aholeintheshieldisforeseenin correspondenceoftheback-neckregion.Manyconfigurationsoftheshieldweretestedintermsof neutronflux,dosedistributionandmeaninducedactivityinthetumourregionandintheradio- sensitiveorgansofthemouse.Inthefinalset-up,uptofivemicecanbetreatedsimultaneouslyinthe reactorthermalcolumnandtheneutronfluenceinthetumourregionfor10minofirradiationisof about 51012 cm2.
2011
The Physics category includes resources of a broad, general nature that contain materials from all areas of physics, The category also includes resources specifically concerned with the following physics sub-fields: mathematical physics, particle and nuclear physics, physics of fluids and plasmas, quantum physics, and theoretical physics.
APPLIED RADIATION AND ISOTOPES
sì
WOS:000297426000057
2-s2.0-80055079972
Esperti anonimi
Inglese
Internazionale
STAMPA
69
12
1842
1845
4
21459587
BNCT; animal irradiation; dosimetry calculation
no
9
info:eu-repo/semantics/article
262
Protti, Nicoletta; Ballarini, Francesca; Bortolussi, Silva; Stella, Sabrina; Bruschi, Piero; Geninatti, Simonetta; Alberti, Diego; Aime, Silvio; Altie...espandi
1 Contributo su Rivista::1.1 Articolo in rivista
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1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/370901
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