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EnglishThis current study showed that down-regulation of NPM1 is rare or is not found in the 5q- syndrome and in other early MDS subtypes with the del(5q), but is common in advanced MDS with the del(5q) and is associated with the presence of a complex karyotype. These data support the hypothesis that reduced expression of NPM1 may play a role in the molecular pathogenesis of advanced MDS with the del(5q) and we suggest that this may be related to a concomitant increase in genomic instability in these cases.
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| Titolo: | Marked down-regulation of nucleophosmin-1 is associated with advanced del(5q) myelodysplastic syndrome | |
| Autori: | ||
| Data di pubblicazione: | 2011 | |
| Rivista: | ||
| Abstract: | This current study showed that down-regulation of NPM1 is rare or is not found in the 5q- syndrome and in other early MDS subtypes with the del(5q), but is common in advanced MDS with the del(5q) and is associated with the presence of a complex karyotype. These data support the hypothesis that reduced expression of NPM1 may play a role in the molecular pathogenesis of advanced MDS with the del(5q) and we suggest that this may be related to a concomitant increase in genomic instability in these cases. | |
| Handle: | http://hdl.handle.net/11571/373916 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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