The work concerns the molecular characterization of the breakpoints of an engineered human minichromosome. The results strongly suggest that a repeated sequence belonging to the L1 family promoted the rearrangement. Thebreakpoint region is part of a new family of human duplicons.
Identification of human pericentromeric DNA sequences promoting chromosome rearrangements
PAULIS, MARIANNA;MORALLI, DANIELA;BENSI, MIRELLA;RAIMONDI, ELENA MARIA
2003-01-01
Abstract
The work concerns the molecular characterization of the breakpoints of an engineered human minichromosome. The results strongly suggest that a repeated sequence belonging to the L1 family promoted the rearrangement. Thebreakpoint region is part of a new family of human duplicons.File in questo prodotto:
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