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Seven clinical isolates of Enterobacteriaceae resistant to third-generation cephalosporins were investigated in order to assess the role played in resistance by permeability barrier and by beta-lactamase production. The addition of subinhibitory concentrations of EDTA increased susceptibility to ceftriaxone in five strains showing that the permeability barrier is involved. All strains produced different amounts of beta-lactamases that were always increased by cefoxitin induction. Hydrolytic activity of investigated enzymes varied in different cephalosporins; ceftriaxone and ceftazidime are the most stable compounds.

Third-generation cephalosporins resistance in clinical isolates of Enterobacteriaceae.

PERDUCA, MARGHERITA;PAGANI, LAURA;CEREDA, PAOLO MARTINO;DEBIAGGI, MAURIZIA
1986-01-01

Abstract

Seven clinical isolates of Enterobacteriaceae resistant to third-generation cephalosporins were investigated in order to assess the role played in resistance by permeability barrier and by beta-lactamase production. The addition of subinhibitory concentrations of EDTA increased susceptibility to ceftriaxone in five strains showing that the permeability barrier is involved. All strains produced different amounts of beta-lactamases that were always increased by cefoxitin induction. Hydrolytic activity of investigated enzymes varied in different cephalosporins; ceftriaxone and ceftazidime are the most stable compounds.
1986
Microbiology covers the biology and biochemistry of microorganisms, bacterial, viral, and parasitic, as well as the medical implications and treatments of the subset of these organisms known to cause disease in humans and/or animals. Biotechnology applications of microorganisms for basic science or clinical use are also covered. Resources that emphasize immune response to pathogens and its modulation by clinical intervention are excluded and are covered in the Immunology category.
MICROBIOLOGICA
sì
A1986C249300009
Sì, ma tipo non specificato
Italiano
Nazionale
STAMPA
9
199
207
3487023
Cephalosporins; pharmacology, Drug Resistance; Microbial, Enterobacteriaceae; drug effects/isolation /&/ purification, Humans, Microbial Sensitivity Tests, Species Specificity, Structure-Activity Relationship, beta-Lactamases; metabolism
4
info:eu-repo/semantics/article
262
Perduca, Margherita; Pagani, Laura; Cereda, PAOLO MARTINO; Debiaggi, Maurizia
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/430972
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