In the early nineties, the progressive interaction between molecular biology and clinical cardiology contributed to the identification of the genetic bases of several inherited diseases causing sudden cardiac death (SCD) in young individuals with a structurally intact heart. The awareness that an “electrical imbalance”, caused by mutations on the genes that encode for cardiac ionic channels, may provoke ventricular arrhythmias and SCD has allowed us to understand that many cases of idiopathic ventricular fibrillation are caused by diseases such as the long QT syndrome (LQTS), the Brugada syndrome (BS), catecholaminergic polymorphic ventricular tachycardia (CPVT) or the recently described short QT syndrome (SQTS).

Molecular genetics: is it making an impact in the management of inherited arrhythmogenic syndromes?

PRIORI, SILVIA GIULIANA;CERRONE, MARINA
2005-01-01

Abstract

In the early nineties, the progressive interaction between molecular biology and clinical cardiology contributed to the identification of the genetic bases of several inherited diseases causing sudden cardiac death (SCD) in young individuals with a structurally intact heart. The awareness that an “electrical imbalance”, caused by mutations on the genes that encode for cardiac ionic channels, may provoke ventricular arrhythmias and SCD has allowed us to understand that many cases of idiopathic ventricular fibrillation are caused by diseases such as the long QT syndrome (LQTS), the Brugada syndrome (BS), catecholaminergic polymorphic ventricular tachycardia (CPVT) or the recently described short QT syndrome (SQTS).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/438476
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