We presentthemagnetic,opticalandrelaxometricpropertiesofmultifunctionalAu–Fe3O4 hybrid nanoparticles(HNPs),aspossiblenovelcontrastagents(CAs)formagneticresonanceimaging(MRI). The HNPshavebeensynthesizedbywetchemicalmethodsinheterodimerandcore–shellgeometries and cappedwitholeylamine.StructuralcharacterizationofthesampleshavebeenmadebyX-ray diffractionandtransmissionelectronmicroscopy,whilemagneticpropertieshavebeeninvestigated by meansofSuperconductingQuantumInterferenceDevice-SQUIDmagnetometryexperiments. As requiredforMRIapplicationsusingnegativeCAs,thesamplesresultedsuperparamagneticatroom temperatureandwellabovetheirblockingtemperatures.Opticalpropertieshavebeeninvestigatedby analyzingtheopticalabsorbtionspectracollectedinUV–visibleregion.Relaxometricmeasurements have beenperformedonorganicsuspensionsofHNPsandNuclearMagneticResonance(NMR) dispersioncurveshavebeenobtainedbymeasuringthelongitudinal1/T1 and transverse1/T2 relaxation ratesofsolventprotonsintherange10kHz/300MHzatroomtemperature.NMRrelaxivities r1 and r2 have beencomparedwithENDOREMs, oneofthecommercialsuperparamagneticironoxidebased MRI contrastagents.MRIcontrastenhancementefficiencieshavebeeninvestigatedalsobyexamining T2-weightedMRimagesofsuspensions.Theexperimentalresultssuggestthatthenanoparticles’ suspensionsaregoodcandidatesasnegativeCAs.

Magnetic, optical and relaxometric properties of organically coated gold-magnetite (Au-Fe3O4) hybrid nanoparticles for potential use in biomedical applications

CORTI, MAURIZIO ENRICO;Lascialfari, A;GHIGNA, PAOLO
2012-01-01

Abstract

We presentthemagnetic,opticalandrelaxometricpropertiesofmultifunctionalAu–Fe3O4 hybrid nanoparticles(HNPs),aspossiblenovelcontrastagents(CAs)formagneticresonanceimaging(MRI). The HNPshavebeensynthesizedbywetchemicalmethodsinheterodimerandcore–shellgeometries and cappedwitholeylamine.StructuralcharacterizationofthesampleshavebeenmadebyX-ray diffractionandtransmissionelectronmicroscopy,whilemagneticpropertieshavebeeninvestigated by meansofSuperconductingQuantumInterferenceDevice-SQUIDmagnetometryexperiments. As requiredforMRIapplicationsusingnegativeCAs,thesamplesresultedsuperparamagneticatroom temperatureandwellabovetheirblockingtemperatures.Opticalpropertieshavebeeninvestigatedby analyzingtheopticalabsorbtionspectracollectedinUV–visibleregion.Relaxometricmeasurements have beenperformedonorganicsuspensionsofHNPsandNuclearMagneticResonance(NMR) dispersioncurveshavebeenobtainedbymeasuringthelongitudinal1/T1 and transverse1/T2 relaxation ratesofsolventprotonsintherange10kHz/300MHzatroomtemperature.NMRrelaxivities r1 and r2 have beencomparedwithENDOREMs, oneofthecommercialsuperparamagneticironoxidebased MRI contrastagents.MRIcontrastenhancementefficiencieshavebeeninvestigatedalsobyexamining T2-weightedMRimagesofsuspensions.Theexperimentalresultssuggestthatthenanoparticles’ suspensionsaregoodcandidatesasnegativeCAs.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/443880
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