We presentthemagnetic,opticalandrelaxometricpropertiesofmultifunctionalAu–Fe3O4 hybrid nanoparticles(HNPs),aspossiblenovelcontrastagents(CAs)formagneticresonanceimaging(MRI). The HNPshavebeensynthesizedbywetchemicalmethodsinheterodimerandcore–shellgeometries and cappedwitholeylamine.StructuralcharacterizationofthesampleshavebeenmadebyX-ray diffractionandtransmissionelectronmicroscopy,whilemagneticpropertieshavebeeninvestigated by meansofSuperconductingQuantumInterferenceDevice-SQUIDmagnetometryexperiments. As requiredforMRIapplicationsusingnegativeCAs,thesamplesresultedsuperparamagneticatroom temperatureandwellabovetheirblockingtemperatures.Opticalpropertieshavebeeninvestigatedby analyzingtheopticalabsorbtionspectracollectedinUV–visibleregion.Relaxometricmeasurements have beenperformedonorganicsuspensionsofHNPsandNuclearMagneticResonance(NMR) dispersioncurveshavebeenobtainedbymeasuringthelongitudinal1/T1 and transverse1/T2 relaxation ratesofsolventprotonsintherange10kHz/300MHzatroomtemperature.NMRrelaxivities r1 and r2 have beencomparedwithENDOREMs, oneofthecommercialsuperparamagneticironoxidebased MRI contrastagents.MRIcontrastenhancementefficiencieshavebeeninvestigatedalsobyexamining T2-weightedMRimagesofsuspensions.Theexperimentalresultssuggestthatthenanoparticles’ suspensionsaregoodcandidatesasnegativeCAs.
Magnetic, optical and relaxometric properties of organically coated gold-magnetite (Au-Fe3O4) hybrid nanoparticles for potential use in biomedical applications
CORTI, MAURIZIO ENRICO;Lascialfari, A;GHIGNA, PAOLO
2012-01-01
Abstract
We presentthemagnetic,opticalandrelaxometricpropertiesofmultifunctionalAu–Fe3O4 hybrid nanoparticles(HNPs),aspossiblenovelcontrastagents(CAs)formagneticresonanceimaging(MRI). The HNPshavebeensynthesizedbywetchemicalmethodsinheterodimerandcore–shellgeometries and cappedwitholeylamine.StructuralcharacterizationofthesampleshavebeenmadebyX-ray diffractionandtransmissionelectronmicroscopy,whilemagneticpropertieshavebeeninvestigated by meansofSuperconductingQuantumInterferenceDevice-SQUIDmagnetometryexperiments. As requiredforMRIapplicationsusingnegativeCAs,thesamplesresultedsuperparamagneticatroom temperatureandwellabovetheirblockingtemperatures.Opticalpropertieshavebeeninvestigatedby analyzingtheopticalabsorbtionspectracollectedinUV–visibleregion.Relaxometricmeasurements have beenperformedonorganicsuspensionsofHNPsandNuclearMagneticResonance(NMR) dispersioncurveshavebeenobtainedbymeasuringthelongitudinal1/T1 and transverse1/T2 relaxation ratesofsolventprotonsintherange10kHz/300MHzatroomtemperature.NMRrelaxivities r1 and r2 have beencomparedwithENDOREMs, oneofthecommercialsuperparamagneticironoxidebased MRI contrastagents.MRIcontrastenhancementefficiencieshavebeeninvestigatedalsobyexamining T2-weightedMRimagesofsuspensions.Theexperimentalresultssuggestthatthenanoparticles’ suspensionsaregoodcandidatesasnegativeCAs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
