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The role played by beta-lactamases and by permeability barrier in resistance to beta-lactam antibiotics was investigated in 250 clinical isolates of Enterobacteriaceae. The data obtained showed that in 73 strains (52.9\%) was a significant correlation between the specific enzyme activity and resistance, however in 38 strains (27.5\%) an essential role was played by permeability barrier because the addition of subinhibitory levels of EDTA produced markedly reduction in the MIC.

[The role of beta-lactamases and the permeability barrier in resistance to beta-lactam antibiotics].

PERDUCA, MARGHERITA;PAGANI, LAURA;ROMERO, EGIDIO
1985-01-01

Abstract

The role played by beta-lactamases and by permeability barrier in resistance to beta-lactam antibiotics was investigated in 250 clinical isolates of Enterobacteriaceae. The data obtained showed that in 73 strains (52.9\%) was a significant correlation between the specific enzyme activity and resistance, however in 38 strains (27.5\%) an essential role was played by permeability barrier because the addition of subinhibitory levels of EDTA produced markedly reduction in the MIC.
1985
Microbiology covers the biology and biochemistry of microorganisms, bacterial, viral, and parasitic, as well as the medical implications and treatments of the subset of these organisms known to cause disease in humans and/or animals. Biotechnology applications of microorganisms for basic science or clinical use are also covered. Resources that emphasize immune response to pathogens and its modulation by clinical intervention are excluded and are covered in the Immunology category.
BOLLETTINO DELL'ISTITUTO SIEROTERAPICO MILANESE
sì
A1985ASS7100005
Sì, ma tipo non specificato
Italiano
Nazionale
STAMPA
64
281
284
3935134
Anti-Bacterial Agents; pharmacology, Cell Membrane Permeability, Drug Resistance; Microbial, Edetic Acid; pharmacology, Enterobacteriaceae; drug effects/enzymology, Humans, beta-Lactamases; metabolism, beta-Lactams
3
info:eu-repo/semantics/article
262
Perduca, Margherita; Pagani, Laura; Romero, Egidio
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/444252
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