The role of autonomic nervous system in the genesis of reperfusion arrhythmias is still controversial. Two confounding factors in the evaluation of the specific role of parasympathetic tone are: the concomitant sympathetic activation occurring rvhen the vago-sympathetic trunk is stimulated in the dog and the reduction in heart rate with the attendant amelioration in the degree of ischemia induced by vagal stimulation. We evaluated the effect of vagotomy and of vagal stimulation on the incidence of reperfusion arrhythmias using an animal species, the feline, in which a pure vagal stimulation can be performed. To avoid any effect on the degree of ischemic damage, vagal stimulation was started only few seconds before reperfusion. Heart rate was either allowed to decrease or kept constant by ventricular pacing.
Protective effect of vagal hyperactivity on reperfusion arrhythmias
DE FERRARI, GAETANO;PRIORI, SILVIA GIULIANA;SCHWARTZ, PETER
1986-01-01
Abstract
The role of autonomic nervous system in the genesis of reperfusion arrhythmias is still controversial. Two confounding factors in the evaluation of the specific role of parasympathetic tone are: the concomitant sympathetic activation occurring rvhen the vago-sympathetic trunk is stimulated in the dog and the reduction in heart rate with the attendant amelioration in the degree of ischemia induced by vagal stimulation. We evaluated the effect of vagotomy and of vagal stimulation on the incidence of reperfusion arrhythmias using an animal species, the feline, in which a pure vagal stimulation can be performed. To avoid any effect on the degree of ischemic damage, vagal stimulation was started only few seconds before reperfusion. Heart rate was either allowed to decrease or kept constant by ventricular pacing.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
