The primary pathogenic trigger in coeliac disease (CD) is still unknown. We present the hypothesis that in CD the enterocytes could metabolize gliadin through an immunogenic pathway instread of a tolerogenic one. The result of this abnornal presentation of gliadin to the immune system would be the activation of lamina propria T cells, followed by the onset of enteropathy.
Is gliadin mispresented to the immune system in coeliac disease? A hypothesis
BIAGI, FEDERICO;
1999-01-01
Abstract
The primary pathogenic trigger in coeliac disease (CD) is still unknown. We present the hypothesis that in CD the enterocytes could metabolize gliadin through an immunogenic pathway instread of a tolerogenic one. The result of this abnornal presentation of gliadin to the immune system would be the activation of lamina propria T cells, followed by the onset of enteropathy.File in questo prodotto:
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