We analyzed telomere lenght in a cohort of MPN patients in order to investigate its relationship with biological and clinical parameters. Patients with MPN present shortened telomeres irrespective of their JAK2 or MPL mutational status, implying that different molecular mechanisms may affect stem cells in the same way, and suggest that telomere assessment may be of potential diagnostic value in the work up of suspected MPN.
Flow-FISH evaluation of telomere length in Philadelphia-negative myeloproliferative neoplasms.
ELENA, CHIARA;RUMI, ELISA;
2011-01-01
Abstract
We analyzed telomere lenght in a cohort of MPN patients in order to investigate its relationship with biological and clinical parameters. Patients with MPN present shortened telomeres irrespective of their JAK2 or MPL mutational status, implying that different molecular mechanisms may affect stem cells in the same way, and suggest that telomere assessment may be of potential diagnostic value in the work up of suspected MPN.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
