Monocyclic Analogs of the mu-opioid Agonist 3,8-diazabicyclo-[3.2.1]octanes - Synthesis, Modeling, and Activity

Barlocco, D.; Villa, S.; Fratta, W.; Fadda, P.; Colombo, D.; Toma, Lucio

doi:10.1016/0040-4020(95)00716-L

Several monocyclic derivatives structurally related to the mu-opioid agonist 3-cinnamyl-8-propionyl-3,8-diazabicyclo[3.2.1]octane have been synthesized and tested in binding studies using the mu-selective H-3-DAMGO as ligand. Modeling studies have been performed on the same compounds in order to explain the observed lack of affinity towards mu-opioid receptors.

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Titolo:	Monocyclic Analogs of the mu-opioid Agonist 3,8-diazabicyclo-[3.2.1]octanes - Synthesis, Modeling, and Activity
Autori:	D. BARLOCCO S. VILLA W. FRATTA P. FADDA D. COLOMBO TOMA, LUCIO mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1995
Rivista:	TETRAHEDRON
Abstract:	Several monocyclic derivatives structurally related to the mu-opioid agonist 3-cinnamyl-8-propionyl-3,8-diazabicyclo[3.2.1]octane have been synthesized and tested in binding studies using the mu-selective H-3-DAMGO as ligand. Modeling studies have been performed on the same compounds in order to explain the observed lack of affinity towards mu-opioid receptors.
Handle:	http://hdl.handle.net/11571/453814
Appare nelle tipologie:	1.1 Articolo in rivista

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