Several monocyclic derivatives structurally related to the mu-opioid agonist 3-cinnamyl-8-propionyl-3,8-diazabicyclo[3.2.1]octane have been synthesized and tested in binding studies using the mu-selective H-3-DAMGO as ligand. Modeling studies have been performed on the same compounds in order to explain the observed lack of affinity towards mu-opioid receptors.
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Titolo: | Monocyclic Analogs of the mu-opioid Agonist 3,8-diazabicyclo-[3.2.1]octanes - Synthesis, Modeling, and Activity | |
Autori: | ||
Data di pubblicazione: | 1995 | |
Rivista: | ||
Abstract: | Several monocyclic derivatives structurally related to the mu-opioid agonist 3-cinnamyl-8-propionyl-3,8-diazabicyclo[3.2.1]octane have been synthesized and tested in binding studies using the mu-selective H-3-DAMGO as ligand. Modeling studies have been performed on the same compounds in order to explain the observed lack of affinity towards mu-opioid receptors. | |
Handle: | http://hdl.handle.net/11571/453814 | |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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