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Several monocyclic derivatives structurally related to the mu-opioid agonist 3-cinnamyl-8-propionyl-3,8-diazabicyclo[3.2.1]octane have been synthesized and tested in binding studies using the mu-selective H-3-DAMGO as ligand. Modeling studies have been performed on the same compounds in order to explain the observed lack of affinity towards mu-opioid receptors.

Monocyclic Analogs of the mu-opioid Agonist 3,8-diazabicyclo-[3.2.1]octanes - Synthesis, Modeling, and Activity

TOMA, LUCIO
1995-01-01

Abstract

Several monocyclic derivatives structurally related to the mu-opioid agonist 3-cinnamyl-8-propionyl-3,8-diazabicyclo[3.2.1]octane have been synthesized and tested in binding studies using the mu-selective H-3-DAMGO as ligand. Modeling studies have been performed on the same compounds in order to explain the observed lack of affinity towards mu-opioid receptors.
1995
The Organic Chemistry/Polymer Science category includes resources concerned with the related fields of organic chemistry and polymer science. The organic chemistry resources deal with compounds of carbon with the exception of certain simple ones, such as the carbon oxides, carbonates, cyanides and cyanates (see Inorganic & Nuclear Chemistry). This category includes research on synthetic and natural organic compounds that may include other elements, such as hydrogen and oxygen, but also nitrogen, halogens, sulphur and phosphorous. Resources concerned with hydrocarbons, organic compounds containing only the elements carbon and hydrogen, are also included in this category. Examples are the alkanes, alkenes, alkynes and aromatics, such as benzene and naphthalene. Polymer science includes all resources dealing with the study, production and technology of polymers, which are compounds composed of very large molecules made up of repeating molecular units (monomers). Polymers may be natural substances, such as polysaccharides or proteins, or synthetic materials, such as nylon or polyethylene.
TETRAHEDRON
sì
WOS:A1995RY77800016
Sì, ma tipo non specificato
Inglese
Internazionale
STAMPA
51
11547
11556
9
6
info:eu-repo/semantics/article
262
D., Barlocco; S., Villa; W., Fratta; P., Fadda; D., Colombo; Toma, Lucio
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/453814
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