Pseudomonas cepacia lipase shows opposite stereoselectivity in the acylation versus the deacylation of diastereoisomeric 1-O- and 3-O-beta-D-glycopyranosyl-sn-glycerols: while the 2,3,4,6-tetraacetylated 1-O-glycosyl-sn-glycerols were the preferred substrates in the former reaction, the 3-O-peracetylated derivatives were hydrolyzed in the latter one. In this way, both 1-O- and 3-O-stereoisomers could be obtained optically pure as residual substrates.
Optically Pure 1-O- and 3-O-beta-D-glucosyl-sn-glycerols and galactosyl-sn-glycerols Through Lipase-catalyzed Transformations
TOMA, LUCIO
1995-01-01
Abstract
Pseudomonas cepacia lipase shows opposite stereoselectivity in the acylation versus the deacylation of diastereoisomeric 1-O- and 3-O-beta-D-glycopyranosyl-sn-glycerols: while the 2,3,4,6-tetraacetylated 1-O-glycosyl-sn-glycerols were the preferred substrates in the former reaction, the 3-O-peracetylated derivatives were hydrolyzed in the latter one. In this way, both 1-O- and 3-O-stereoisomers could be obtained optically pure as residual substrates.File in questo prodotto:
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