IRIS

The conformational space of the tetrasaccharide alpha-L-Fuc-(1 --> 2)-beta-D-Gal-(1 --> 3)-beta-D-GalNAc-(1 --> 3)-alpha -D-Gal1Pr (3) and of some overlapping di- and trisaccharide sequences was investigated with the aid of molecular-mechanics energy minimizations, molecular-dynamics simulations, and H-1-NMR analysis. These investigations suggested that in compound:) a certain rigidity of the first two glycosidic linkages (Fuc-Gal and Gal-GalNAc) is combined with the flexibility of the third one (GalNAc-Gal).

Oligosaccharides Related To Tumor-associate Antigens .4. Modeling of the Terminal Tetrasaccharide of An Antigen Recognized By the Mbr1 Antibody and of Overlapping Disaccharide and Trisaccharide Sequences

TOMA, LUCIO;
1995-01-01

Abstract

The conformational space of the tetrasaccharide alpha-L-Fuc-(1 --> 2)-beta-D-Gal-(1 --> 3)-beta-D-GalNAc-(1 --> 3)-alpha -D-Gal1Pr (3) and of some overlapping di- and trisaccharide sequences was investigated with the aid of molecular-mechanics energy minimizations, molecular-dynamics simulations, and H-1-NMR analysis. These investigations suggested that in compound:) a certain rigidity of the first two glycosidic linkages (Fuc-Gal and Gal-GalNAc) is combined with the flexibility of the third one (GalNAc-Gal).
1995
The Organic Chemistry/Polymer Science category includes resources concerned with the related fields of organic chemistry and polymer science. The organic chemistry resources deal with compounds of carbon with the exception of certain simple ones, such as the carbon oxides, carbonates, cyanides and cyanates (see Inorganic & Nuclear Chemistry). This category includes research on synthetic and natural organic compounds that may include other elements, such as hydrogen and oxygen, but also nitrogen, halogens, sulphur and phosphorous. Resources concerned with hydrocarbons, organic compounds containing only the elements carbon and hydrogen, are also included in this category. Examples are the alkanes, alkenes, alkynes and aromatics, such as benzene and naphthalene. Polymer science includes all resources dealing with the study, production and technology of polymers, which are compounds composed of very large molecules made up of repeating molecular units (monomers). Polymers may be natural substances, such as polysaccharides or proteins, or synthetic materials, such as nylon or polyethylene.
HELVETICA CHIMICA ACTA
sì
WOS:A1995QZ21000010
Sì, ma tipo non specificato
Inglese
Internazionale
STAMPA
78
636
646
10
5
info:eu-repo/semantics/article
262
Toma, Lucio; D., Colombo; F., Ronchetti; L., Panza; G., Russo
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/453816
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 7
social impact