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The conformational space of the trisaccharide alpha-L-Fuc-(1 --> 2)-beta-D-Gal-(1 --> 3)-beta-D-GalNAc-1-OPr (2) and of its component disaccharide moieties alpha-L-Fuc-(1 --> 2)-beta-D-Gal-1-OMe (3) and beta-D-Gal-(1 --> 3)-beta-D-GalNAc-1-OPr (4) was investigated with the aid of molecular-mechanics energy minimizations and molecular-dynamics simulations. These calculations suggested the occurrence of two conformations for each compound characterized by different phi and psi glycosidic angles. However, H-1-NMR investigation of D2O solutions of 2-4 indicated a sure preference for one of the two conformers with a contribution of the other one ranging from negligible to low.

Oligosaccharides Related To Tumor-associate Antigens .2. Conformational-analysis of the Trisaccharide Alpha-L-fucp-(1-2)-beta-D-galp-(1-3)-beta-D-galpNAc, Epitope Structure Recognized By the Mbr1 Antibody

TOMA, LUCIO;
1994-01-01

Abstract

The conformational space of the trisaccharide alpha-L-Fuc-(1 --> 2)-beta-D-Gal-(1 --> 3)-beta-D-GalNAc-1-OPr (2) and of its component disaccharide moieties alpha-L-Fuc-(1 --> 2)-beta-D-Gal-1-OMe (3) and beta-D-Gal-(1 --> 3)-beta-D-GalNAc-1-OPr (4) was investigated with the aid of molecular-mechanics energy minimizations and molecular-dynamics simulations. These calculations suggested the occurrence of two conformations for each compound characterized by different phi and psi glycosidic angles. However, H-1-NMR investigation of D2O solutions of 2-4 indicated a sure preference for one of the two conformers with a contribution of the other one ranging from negligible to low.
1994
The Organic Chemistry/Polymer Science category includes resources concerned with the related fields of organic chemistry and polymer science. The organic chemistry resources deal with compounds of carbon with the exception of certain simple ones, such as the carbon oxides, carbonates, cyanides and cyanates (see Inorganic & Nuclear Chemistry). This category includes research on synthetic and natural organic compounds that may include other elements, such as hydrogen and oxygen, but also nitrogen, halogens, sulphur and phosphorous. Resources concerned with hydrocarbons, organic compounds containing only the elements carbon and hydrogen, are also included in this category. Examples are the alkanes, alkenes, alkynes and aromatics, such as benzene and naphthalene. Polymer science includes all resources dealing with the study, production and technology of polymers, which are compounds composed of very large molecules made up of repeating molecular units (monomers). Polymers may be natural substances, such as polysaccharides or proteins, or synthetic materials, such as nylon or polyethylene.
HELVETICA CHIMICA ACTA
sì
WOS:A1994NM08200009
Sì, ma tipo non specificato
Inglese
Internazionale
STAMPA
77
668
678
10
6
info:eu-repo/semantics/article
262
Toma, Lucio; P., Ciuffreda; D., Colombo; F., Ronchetti; L., Lay; L., Panza
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/453822
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