A series of dinitro and monoamino-mononitro analogues of the 5,6diphenyl-3-alkylaminopyridazines were synthesized and their structure was assigned on the basis of mono and bidimensional NMR experiments. Their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. Theoretical studies were performed to correlate the activity of the compounds to their structural features.
5,6-dinitrophenyl and 5-aminophenyl-6-nitrophenyl analogues of the ACAT inhibitor 5,6-diphenyl-3-alkylaminopyridazines
TOMA, LUCIO;
2000-01-01
Abstract
A series of dinitro and monoamino-mononitro analogues of the 5,6diphenyl-3-alkylaminopyridazines were synthesized and their structure was assigned on the basis of mono and bidimensional NMR experiments. Their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. Theoretical studies were performed to correlate the activity of the compounds to their structural features.File in questo prodotto:
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