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A series of trimethylpiperazine derivatives; structurally related to the mu-agonist 3-cinnamyl-8-propionyl-3,8-diazabicyclo[3.2.1]octane, have been synthesized and tested in binding studies, using H-3-DAMGO as mu-selective ligand. Their different affinity towards mu-opioid receptors has been interpreted on the basis of a molecular modeling study performed through molecular mechanics calculations and high field H-1 MNR spectroscopy. (C) 1997, Elsevier Science Ltd.

2,2,6- and 2,3,5-trimethylpiperazines as monocyclic analogues of the mu-opioid agonist 3,8-diazabicyclo[3.2.1]octanes: Synthesis, modeling, and activity

TOMA, LUCIO
1997-01-01

Abstract

A series of trimethylpiperazine derivatives; structurally related to the mu-agonist 3-cinnamyl-8-propionyl-3,8-diazabicyclo[3.2.1]octane, have been synthesized and tested in binding studies, using H-3-DAMGO as mu-selective ligand. Their different affinity towards mu-opioid receptors has been interpreted on the basis of a molecular modeling study performed through molecular mechanics calculations and high field H-1 MNR spectroscopy. (C) 1997, Elsevier Science Ltd.
1997
The Organic Chemistry/Polymer Science category includes resources concerned with the related fields of organic chemistry and polymer science. The organic chemistry resources deal with compounds of carbon with the exception of certain simple ones, such as the carbon oxides, carbonates, cyanides and cyanates (see Inorganic & Nuclear Chemistry). This category includes research on synthetic and natural organic compounds that may include other elements, such as hydrogen and oxygen, but also nitrogen, halogens, sulphur and phosphorous. Resources concerned with hydrocarbons, organic compounds containing only the elements carbon and hydrogen, are also included in this category. Examples are the alkanes, alkenes, alkynes and aromatics, such as benzene and naphthalene. Polymer science includes all resources dealing with the study, production and technology of polymers, which are compounds composed of very large molecules made up of repeating molecular units (monomers). Polymers may be natural substances, such as polysaccharides or proteins, or synthetic materials, such as nylon or polyethylene.
TETRAHEDRON
sì
WOS:A1997WD99000022
Sì, ma tipo non specificato
Inglese
Internazionale
STAMPA
53
1481
1490
9
5
info:eu-repo/semantics/article
262
M., Ballabio; D., Barlocco; G., Cignarella; D., Colombo; Toma, Lucio
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/455821
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