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EnglishThe in vitro anti-tumor promoting effect of monohexanoates of 2-O-alpha -D-gluco- and galactopyranosyl-sn-glycerol on the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced Epstein-Barr virus early antigen (EBV-EA) activation was evaluated and compared to the potencies of the corresponding beta -anomers. The results show that the inversion of the anomeric configuration from beta to alpha does not seem to significantly influence the activity, which is present, as for the beta -anomers, even at 1 x 10 mol ratio without any cytotoxicity. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
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| Titolo: | Glycoglycerolipid analogues active as anti-tumor-promoters: the influence of the anomeric configuration |
| Autori: | |
| Data di pubblicazione: | 2000 |
| Rivista: | |
| Abstract: | The in vitro anti-tumor promoting effect of monohexanoates of 2-O-alpha -D-gluco- and galactopyranosyl-sn-glycerol on the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced Epstein-Barr virus early antigen (EBV-EA) activation was evaluated and compared to the potencies of the corresponding beta -anomers. The results show that the inversion of the anomeric configuration from beta to alpha does not seem to significantly influence the activity, which is present, as for the beta -anomers, even at 1 x 10 mol ratio without any cytotoxicity. (C) 2000 Editions scientifiques et medicales Elsevier SAS. |
| Handle: | http://hdl.handle.net/11571/456034 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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