The in vitro anti-tumor promoting effect of monohexanoates of 2-O-alpha -D-gluco- and galactopyranosyl-sn-glycerol on the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced Epstein-Barr virus early antigen (EBV-EA) activation was evaluated and compared to the potencies of the corresponding beta -anomers. The results show that the inversion of the anomeric configuration from beta to alpha does not seem to significantly influence the activity, which is present, as for the beta -anomers, even at 1 x 10 mol ratio without any cytotoxicity. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

Glycoglycerolipid analogues active as anti-tumor-promoters: the influence of the anomeric configuration

TOMA, LUCIO;
2000

Abstract

The in vitro anti-tumor promoting effect of monohexanoates of 2-O-alpha -D-gluco- and galactopyranosyl-sn-glycerol on the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced Epstein-Barr virus early antigen (EBV-EA) activation was evaluated and compared to the potencies of the corresponding beta -anomers. The results show that the inversion of the anomeric configuration from beta to alpha does not seem to significantly influence the activity, which is present, as for the beta -anomers, even at 1 x 10 mol ratio without any cytotoxicity. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11571/456034
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 17
social impact