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The in vitro anti-tumor promoting effect of monohexanoates of 2-O-alpha -D-gluco- and galactopyranosyl-sn-glycerol on the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced Epstein-Barr virus early antigen (EBV-EA) activation was evaluated and compared to the potencies of the corresponding beta -anomers. The results show that the inversion of the anomeric configuration from beta to alpha does not seem to significantly influence the activity, which is present, as for the beta -anomers, even at 1 x 10 mol ratio without any cytotoxicity. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

Glycoglycerolipid analogues active as anti-tumor-promoters: the influence of the anomeric configuration

TOMA, LUCIO;
2000-01-01

Abstract

The in vitro anti-tumor promoting effect of monohexanoates of 2-O-alpha -D-gluco- and galactopyranosyl-sn-glycerol on the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced Epstein-Barr virus early antigen (EBV-EA) activation was evaluated and compared to the potencies of the corresponding beta -anomers. The results show that the inversion of the anomeric configuration from beta to alpha does not seem to significantly influence the activity, which is present, as for the beta -anomers, even at 1 x 10 mol ratio without any cytotoxicity. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
2000
The Organic Chemistry/Polymer Science category includes resources concerned with the related fields of organic chemistry and polymer science. The organic chemistry resources deal with compounds of carbon with the exception of certain simple ones, such as the carbon oxides, carbonates, cyanides and cyanates (see Inorganic & Nuclear Chemistry). This category includes research on synthetic and natural organic compounds that may include other elements, such as hydrogen and oxygen, but also nitrogen, halogens, sulphur and phosphorous. Resources concerned with hydrocarbons, organic compounds containing only the elements carbon and hydrogen, are also included in this category. Examples are the alkanes, alkenes, alkynes and aromatics, such as benzene and naphthalene. Polymer science includes all resources dealing with the study, production and technology of polymers, which are compounds composed of very large molecules made up of repeating molecular units (monomers). Polymers may be natural substances, such as polysaccharides or proteins, or synthetic materials, such as nylon or polyethylene.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
sì
WOS:000166703400007
Sì, ma tipo non specificato
Inglese
Internazionale
STAMPA
35
1109
1113
4
7
info:eu-repo/semantics/article
262
D., Colombo; F., Compostella; F., Ronchetti; A., Scala; Toma, Lucio; H., Tokuda; H., Nishino
1 Contributo su Rivista::1.1 Articolo in rivista
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1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/456034
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