Some 7-piperazinoquinolones undergo smooth cathodic defluorination in aqueous buffer (pH7.2) at -1.35V vs Ag/AgCl via an ECE mechanism; a 6-fluoro derivative is reduced, a 6,8-difluoro analogue is selectively reduced at position 8.
First electrochemical defluorination in heterocyclic chemistry. Mild cathodic reduction of some fluoroquinolones
PROFUMO, ANTONELLA;FASANI, ELISA;ALBINI, ANGELO
1999-01-01
Abstract
Some 7-piperazinoquinolones undergo smooth cathodic defluorination in aqueous buffer (pH7.2) at -1.35V vs Ag/AgCl via an ECE mechanism; a 6-fluoro derivative is reduced, a 6,8-difluoro analogue is selectively reduced at position 8.File in questo prodotto:
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