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This paper describes the improvements in r-HuEPO therapy of uremic patients that may be obtained by using a mathematical model of patient response together with a delivery control strategy derived from the theory of industrial control. A mathematical model of r-HuEPO action is presented, and its applicability to dialytic patients is shown. Moreover, a new statistical technique for identifying the parameters of the mathematical model analyzing a patient population is summarized, and a control strategy for r-HuEPO delivery in uremic patients based on a Fuzzy Set Controller is introduced. Some results obtained from simulation, are presented.

Mathematical modeling of erythropoietin therapy in uremic anemia. Does it improve cost-effectiveness?

BELLAZZI, RICCARDO;
1994-01-01

Abstract

This paper describes the improvements in r-HuEPO therapy of uremic patients that may be obtained by using a mathematical model of patient response together with a delivery control strategy derived from the theory of industrial control. A mathematical model of r-HuEPO action is presented, and its applicability to dialytic patients is shown. Moreover, a new statistical technique for identifying the parameters of the mathematical model analyzing a patient population is summarized, and a control strategy for r-HuEPO delivery in uremic patients based on a Fuzzy Set Controller is introduced. Some results obtained from simulation, are presented.
1994
Medical Research, Diagnosis & Treatment contains studies of existing and developing diagnostic and therapeutic techniques, as well as specific classes of clinical intervention. Resources in this category emphasize the difference between normal and disease states, with the ultimate goal of more effective diagnosis and intervention. Specific areas of interest include pathology and histochemical analysis of tissue, clinical chemistry and biochemical analysis of medical samples, diagnostic imaging, radiology and radiation, surgical research, anesthesiology and anesthesia, transplantation, artificial tissues, and medical implants. Resources focused on the disease, diagnosis, and treatment of specific organs or physiological systems are excluded and are covered in the Medical Research: Organs & Systems category.
HAEMATOLOGICA
sì
WOS:A1994NH74200009
2-s2.0-0028232996
Sì, ma tipo non specificato
Inglese
Internazionale
STAMPA
79
2
154
164
11
8063263
Mathematical models; Erythropoietin; renal anemia
3
info:eu-repo/semantics/article
262
Bellazzi, Riccardo; Siviero, C; Bellazzi, R.
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/456869
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