The dioxolenonemethyl moiety of the oral penem prodrug FCE 25199 (1) was found to be a source of photochemical lability in the solid state. Reactions centered on the formation and decomposition of a hydroperoxide (3) have been observed and rationalized. Expedients have been devised to improve the shelf-life of crystalline 1 up to acceptable levels.
Solid state photoreactivity of a dioxolenone methyl ester
ALBINI, ANGELO;FASANI, ELISA;
1995-01-01
Abstract
The dioxolenonemethyl moiety of the oral penem prodrug FCE 25199 (1) was found to be a source of photochemical lability in the solid state. Reactions centered on the formation and decomposition of a hydroperoxide (3) have been observed and rationalized. Expedients have been devised to improve the shelf-life of crystalline 1 up to acceptable levels.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
