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The dioxolenonemethyl moiety of the oral penem prodrug FCE 25199 (1) was found to be a source of photochemical lability in the solid state. Reactions centered on the formation and decomposition of a hydroperoxide (3) have been observed and rationalized. Expedients have been devised to improve the shelf-life of crystalline 1 up to acceptable levels.

Solid state photoreactivity of a dioxolenone methyl ester

ALBINI, ANGELO;FASANI, ELISA;
1995-01-01

Abstract

The dioxolenonemethyl moiety of the oral penem prodrug FCE 25199 (1) was found to be a source of photochemical lability in the solid state. Reactions centered on the formation and decomposition of a hydroperoxide (3) have been observed and rationalized. Expedients have been devised to improve the shelf-life of crystalline 1 up to acceptable levels.
1995
The Chemistry category includes resources that are general in nature and cover a broad spectrum of topics in the chemical sciences. Resources specifically covering analytical chemistry, inorganic and nuclear chemistry, organic chemistry, physical chemistry, and polymer science will be placed in those particular categories. Miscellaneous and applied chemistry resources may be placed in this category when not appropriate for specific subfields in chemistry.
TETRAHEDRON LETTERS
sì
Sì, ma tipo non specificato
Inglese
Internazionale
ELETTRONICO
36
4633
4636
4
photoreactivity; dioxolenone methyl ester
6
info:eu-repo/semantics/article
262
Albini, Angelo; Alpegiani, M.; Borghi, D.; Del Nero, S.; Fasani, Elisa; Perrone, E.
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/460506
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