A carrot cell line (WCA1) resistant to Mtx has been isolated and partially characterizaed. The IC50-Mtx is about thirty times higher in the resistant than in the parental line and the rate of uptake of Mtx is decreased 14 times. In addition the specific activity of DHFR is about three times higher in the resistant line as compared to the parent
Isolation and characterization of a carrot cell line resistant to methotrexate.
CELLA, RINO;
1984-01-01
Abstract
A carrot cell line (WCA1) resistant to Mtx has been isolated and partially characterizaed. The IC50-Mtx is about thirty times higher in the resistant than in the parental line and the rate of uptake of Mtx is decreased 14 times. In addition the specific activity of DHFR is about three times higher in the resistant line as compared to the parentFile in questo prodotto:
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