This review deals with recent findings in tlie purification and characterization of dihydrofolate reductase (DHFR) and thymidylate synthase (TS) in plants. The few enzymes purified, which differ remarkably in regard to their structure, kinetic and molecular properties and subcellular location are described. The response of DHFRs to antifolic agents and the analysis of resistance mechanisms in isolated cell lines is also reported. Problems opened by recent studies of the enzymes isolated from plants are outlined.

Dihydrofolate reductase and thymidylate synthase in plants: an open problem.

CELLA, RINO;
1993-01-01

Abstract

This review deals with recent findings in tlie purification and characterization of dihydrofolate reductase (DHFR) and thymidylate synthase (TS) in plants. The few enzymes purified, which differ remarkably in regard to their structure, kinetic and molecular properties and subcellular location are described. The response of DHFRs to antifolic agents and the analysis of resistance mechanisms in isolated cell lines is also reported. Problems opened by recent studies of the enzymes isolated from plants are outlined.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/465119
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