The goal is to study the effect of mechanical grinding on crystallinity changes of naproxen in mixtures with crystalline and amorphous alpha-cyclodextrin and maltohexaose (M6); and the possible formation of a pseudo-inclusion complex between naproxen and M6 in aqueous solution. The intrinsically amorphous linear analog of alpha-cyclodextrin might be a potential amorphism – inducing agent and solubilizer for scarcely water soluble drugs.
Interaction of naproxen with alpha-cyclodextrin and its noncyclic analog maltohexaose
BETTINETTI, GIAMPIERO;SORRENTI, MILENA LILLINA;SETTI, MASSIMO;
1999-01-01
Abstract
The goal is to study the effect of mechanical grinding on crystallinity changes of naproxen in mixtures with crystalline and amorphous alpha-cyclodextrin and maltohexaose (M6); and the possible formation of a pseudo-inclusion complex between naproxen and M6 in aqueous solution. The intrinsically amorphous linear analog of alpha-cyclodextrin might be a potential amorphism – inducing agent and solubilizer for scarcely water soluble drugs.File in questo prodotto:
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