In the title monohydrate salt of ambroxol (AMB) with theophylline-7-acetic acid (TAA), protonation of the secondary amino group of AMB takes place. An hydrogen bond is established between the protonated N atom and an O atom of the carboxylate anion, the same atom as is involved in an N-HO interaction with the aromatic amino group of the cation. The other O atom of the carboxylate anion participates in an hydrogen bond with a symmetry-related salt molecule, giving rise to a dimeric arrangement. The water molecule is linked to a carbonyl O atom of TAA and the aromatic amino group of AMB, and connects the salt molecules in the crystal at the level of the OH group of AMB.
Ambroxol theophylline-7-acetate salt monohydrate
BETTINETTI, GIAMPIERO;SORRENTI, MILENA LILLINA;
1998-01-01
Abstract
In the title monohydrate salt of ambroxol (AMB) with theophylline-7-acetic acid (TAA), protonation of the secondary amino group of AMB takes place. An hydrogen bond is established between the protonated N atom and an O atom of the carboxylate anion, the same atom as is involved in an N-HO interaction with the aromatic amino group of the cation. The other O atom of the carboxylate anion participates in an hydrogen bond with a symmetry-related salt molecule, giving rise to a dimeric arrangement. The water molecule is linked to a carbonyl O atom of TAA and the aromatic amino group of AMB, and connects the salt molecules in the crystal at the level of the OH group of AMB.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
