The aim of the study was to evaluate in man the dose-effect relationship of ibopamine solution 0.25\%, 0.50\% and 1\% on the pupillary diameter and the pupillary reflex to light stimulus and near vision. A cross-over study was performed in comparison with a placebo and with tropicamide solution 1\% in 18 healthy volunteers. The results show that ibopamine 1\% determines a marked mydriatic effect. At the doses used, it produces a maximum increase of the pupillary diameter with a dose-effect relationship which does not depart significantly from a straight line. The maximum mydriatic effect of ibopamine 1\% is significantly greater than that of tropicamide 1\%. The mydriatic effect of ibopamine lasts for about 3 h; that of tropicamide lasts longer. Tropicamide 1\% markedly and for a long period inhibits the pupillary reflex both to light and to near vision. The effect of ibopamine 1\% on the pupillary reflex to near vision is slight, while on the reflex to light stimulus it is essentially comparable to that of tropicamide.
Dynamic evaluation by TV-pupillometry of the mydriatic effect of ibopamine solution. Controlled studies.
TASSORELLI, CRISTINA;
1990-01-01
Abstract
The aim of the study was to evaluate in man the dose-effect relationship of ibopamine solution 0.25\%, 0.50\% and 1\% on the pupillary diameter and the pupillary reflex to light stimulus and near vision. A cross-over study was performed in comparison with a placebo and with tropicamide solution 1\% in 18 healthy volunteers. The results show that ibopamine 1\% determines a marked mydriatic effect. At the doses used, it produces a maximum increase of the pupillary diameter with a dose-effect relationship which does not depart significantly from a straight line. The maximum mydriatic effect of ibopamine 1\% is significantly greater than that of tropicamide 1\%. The mydriatic effect of ibopamine lasts for about 3 h; that of tropicamide lasts longer. Tropicamide 1\% markedly and for a long period inhibits the pupillary reflex both to light and to near vision. The effect of ibopamine 1\% on the pupillary reflex to near vision is slight, while on the reflex to light stimulus it is essentially comparable to that of tropicamide.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.