Background: Inhibin B (IB) and Anti-Müllerian hormone (AMH) are produced by the granulosa cells in small antral follicles and are sensitive markers of ovarian follicular activity. Unlike the IB, the AMH production has never been evaluated in girls with sexual precocity. Objective and hypotheses: The aim of this study was to determine the IB and AMH production in girls with premature thelarche (PT) and with central precocious puberty (CPP) and to investigate whether the production of these two hormones is influenced by the Gn-RHa therapy. Method: Heighty-seven girls were enrolled in this study: 25 girls with PT (1.2-7.8 yrs) and 62 girls with CPP of whom 30 girls (1.4-9.1 yrs) before Gn- RHa therapy and 32 (5.9-12.4 yrs) during Gn-RHa therapy. The control group consisted of 26 healthy prepubertal age-matched girls. Results: Inhibin B levels were higher in girls with PT and with CPP than in controls; the IB concentrations decreased during GN-RHa therapy. Unlike IB, AMH levels were significantly (p=0.011) lower in girls with PT than in girls with CPP, during GnRH-a treatment the AMH concentrations didn’t show variation respect to pretreatment values. The AMH levels were significantly (p<0,005) higher in girls showing at ultrasound (US) examination a paucior multi-follicular ovarian pattern than in those with homogeneous pattern, no differences were found between IB levels and US ovarian morphology. A positive correlation was found between IB and FSH levels and between AMH and estradiol levels. Conclusions: AMH showed a different trend from IB in patients with PT and CPP. AMH levels better correlate than IB with the ovarian morphology and therefore seem to be more specific than IB in showing the presence of follicular activity. Unlike IB, AMH production didn’t decrease during Gn-RHa therapy, this suggests that other factors other than the gonadotropins may regulate the ovarian follicular activity.
Serum Anti-Müllerian Hormone (AMH) and Inhibin (IB) levels in girls with isolated premature thelarche and with central precocious puberty
CISTERNINO, MARIANGELA;
2011-01-01
Abstract
Background: Inhibin B (IB) and Anti-Müllerian hormone (AMH) are produced by the granulosa cells in small antral follicles and are sensitive markers of ovarian follicular activity. Unlike the IB, the AMH production has never been evaluated in girls with sexual precocity. Objective and hypotheses: The aim of this study was to determine the IB and AMH production in girls with premature thelarche (PT) and with central precocious puberty (CPP) and to investigate whether the production of these two hormones is influenced by the Gn-RHa therapy. Method: Heighty-seven girls were enrolled in this study: 25 girls with PT (1.2-7.8 yrs) and 62 girls with CPP of whom 30 girls (1.4-9.1 yrs) before Gn- RHa therapy and 32 (5.9-12.4 yrs) during Gn-RHa therapy. The control group consisted of 26 healthy prepubertal age-matched girls. Results: Inhibin B levels were higher in girls with PT and with CPP than in controls; the IB concentrations decreased during GN-RHa therapy. Unlike IB, AMH levels were significantly (p=0.011) lower in girls with PT than in girls with CPP, during GnRH-a treatment the AMH concentrations didn’t show variation respect to pretreatment values. The AMH levels were significantly (p<0,005) higher in girls showing at ultrasound (US) examination a paucior multi-follicular ovarian pattern than in those with homogeneous pattern, no differences were found between IB levels and US ovarian morphology. A positive correlation was found between IB and FSH levels and between AMH and estradiol levels. Conclusions: AMH showed a different trend from IB in patients with PT and CPP. AMH levels better correlate than IB with the ovarian morphology and therefore seem to be more specific than IB in showing the presence of follicular activity. Unlike IB, AMH production didn’t decrease during Gn-RHa therapy, this suggests that other factors other than the gonadotropins may regulate the ovarian follicular activity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
