A multidisciplinary approach to the design of novel inhibitors for KPC-2

Background. The emergence and dissemination of multi drug resistant (MDR) Gram-negative pathogens resistant to all available antibiotics poses a significant threat in clinical therapy. Among them, Klebsiella Pneumoniae clinical isolates overexpressing KPC-2 carbapenemase are the most worrisome, extending bacterial resistance to last resort carbapenems. [1-2] Materials/methods. Four boronic acid derivatives were designed and tested in vitro vs KPC-2.[3] In biological assays their ability to...

New weapons against antimicrobial resistance: 
Targeting SOS response to recover b
 actericidal activity of antibiotics


Drug Resistant Bacteria represent a global emergency, limiting the effective treatment of bacterial infections.The development of novel strategies fighting bacterial infections is strongly desirable. One such approach is a means of prolonging the lifespan of current antibiotics, namely, the development of antibiotic adjuvants, i.e. compounds that do not themselves kill bacteria but instead enhance the effect of an antibiotic. Adjuvants have potential application in a number of situations, wit...

Scouting Sigma Receptor Ligands As New Tools For The Treatment Of Neurodegenerative Diseases And Cancer

Sigma receptors (Rs) are nowadays recognized as an unique class of membrane receptors divided into two subtypes, R and R. Rs regulate a number of physiological functions and their role has been evaluated in many disorders. Deficits in R are associated with neurodegeneration while their activation may represent a valuable strategy for the treatment of a number of neurodegenerative disorders. Moreover, R is overexpressed in a variety of cancer cells and selective R antagonists are r...

Network Authentication with Synchronized Chaotic Lasers