Human lymphocytes pooled are used as an experimental model to evaluate the effect of physical and chemical agents. The results indicate that a pool of human peripheral lymphocytes can be conveniently used as an alternative to heteroploid cell lines and diploid fibroblasts in DNA repair assays.

Validation of a DNA-repair synthesis assay on pools of fresh and frozen-thawed lymphocytes

CAPELLI, ENRICA;GIULOTTO, ELENA;
1982-01-01

Abstract

Human lymphocytes pooled are used as an experimental model to evaluate the effect of physical and chemical agents. The results indicate that a pool of human peripheral lymphocytes can be conveniently used as an alternative to heteroploid cell lines and diploid fibroblasts in DNA repair assays.
1982
Molecular Biology & Genetics considers all aspects of basic and applied genetics, including molecular genetics, prokaryotic and eukaryotic gene expression, mechanisms of mutagenesis, structure, function and regulation of genetic material. Also included are resources concerned with clinical genetics, patterns of inheritance, genetic cause, and screening and treatment of disease. Resources dealing specifically with developmentally regulated gene expression, or with signal transduction pathways that modulate gene expression at the cellular level are excluded and are covered in the Cell and Developmental Biology category.
Sì, ma tipo non specificato
Inglese
Internazionale
STAMPA
104
187
191
5
DNA Repair; DNA Replication; Dose-Response Relationship; drugs; lymphocytes
4
info:eu-repo/semantics/article
262
Capelli, Enrica; Stefanini, M.; Giulotto, Elena; Nuzzo, F.
1 Contributo su Rivista::1.1 Articolo in rivista
none
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/580871
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 4
  • ???jsp.display-item.citation.isi??? ND
social impact