Immunoglobulin production pattern in allergic and non-allergic subjects

Allergic rhinitis (AR) is characterized by Th2 polarized immune response, such as increased IL-4 and reduced IFN-gamma production, and by a functional defect of T regulatory cells This impaired immune response profile influences the pattern of immunoglobulin (Ig) production in allergic patients However, no studies have compared the pattern of inhalant allergen-specific Ig classes between allergic patients and normal subjects The aim of this study is to therefore investigate the allergen-specific IgE, IgG, IgG4, and IgA serum level pattern in a group of patients with pollen allergy and in non-allergic healthy subjects One hundred and two allergic patients (evaluated both out of and in the pollen season) were enrolled In addition, 50 healthy non-allergic subjects were recruited during the whole year Serum allergen-specific IgE, IgG, IgG4, and IgA for Parietaria, grasses, and birch were quantitatively determined by the ImmunoCAP System method Allergen-specific IgE, IgG, IgG4, and IgA serum levels were significantly different for each tested allergen (p=0 0001 for each class) among groups Allergic patients, mainly during pollen season, showed the highest IgG, IgG4, and IgA levels The present study therefore provides the preliminary evidence that Ig production pattern toward inhalant allergens may depend on the specificity of the allergenic response both in non-allergic subjects and allergic patients Allergic patients do not show a defect of IgG and IgA classes In addition, this study is the first that quantitatively evaluates the Ig classes However, further studies should include non-allergic subjects evaluated both during and out of the pollen season