The aim of the present study was to identify the true extent of the non-responsiveness in infants born from HBsAg-negative mothers, vaccinated against Hepatitis B Virus ( HBV) at birh. Sixty-four non - and low-responding infants, selected from an initial cohort of 2009, were given two additional doses of recombinant HBV vaccine between the tenth and the twelfth month of age. A parallel evaluation was conducted on the response to anti-rubella and anti-tetanus vaccine. Only two infants remained non-responders, whereas 68% of the non-responders and 94% of the low responders after the primary vaccination schedule developed antibody titres over 100 mlU ml-1. No significant relationship between the specific antibody level against HBV and against rubella or tenatus 1 month after vaccination was observed.
Revaccination against hepatitis B virus of non-responding and low-responding infants immunised a birth. A parallel evaluation of rubella and tetanus vaccine
ORSOLINI, PAOLO;
1998-01-01
Abstract
The aim of the present study was to identify the true extent of the non-responsiveness in infants born from HBsAg-negative mothers, vaccinated against Hepatitis B Virus ( HBV) at birh. Sixty-four non - and low-responding infants, selected from an initial cohort of 2009, were given two additional doses of recombinant HBV vaccine between the tenth and the twelfth month of age. A parallel evaluation was conducted on the response to anti-rubella and anti-tetanus vaccine. Only two infants remained non-responders, whereas 68% of the non-responders and 94% of the low responders after the primary vaccination schedule developed antibody titres over 100 mlU ml-1. No significant relationship between the specific antibody level against HBV and against rubella or tenatus 1 month after vaccination was observed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
