Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naive HIV-1-infected patients, with a genotypic resistance test (GRT) performed <6 months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtypeB). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs B subtype predicted lower odds of TDR.
Evolution of transmitted HIV-1 drug resistance in HIV-1 infected patients in Italy from 2000 to 2010.
FILICE, GAETANO;
2012-01-01
Abstract
Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naive HIV-1-infected patients, with a genotypic resistance test (GRT) performed <6 months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtypeB). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs B subtype predicted lower odds of TDR.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
