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BNCT wasproposedforthetreatmentofdiffuse,non-Resectabletumorsinthelung.Weperformedboron biodistribution studies with 5 administration protocols employing the boron carriers BPA and orGB-10 in an experimental model of disseminated lung metastases in rats. All 5 protocols were non-toxic and showed preferential tumor boron uptake versusl ung. Absolute tumor boronconcentrationvalueswere therapeuticallyuseful(25–76ppm)for3protocols.DosimetriccalculationsindicatethatBNCTatRA-3 would bepotentially therapeutic without exceeding radiotolerance in the lung.

Biodistribution of the boron carriers boronophenylalanine (BPA) and/or decahydrodecaborate (GB-10) for Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases

BORTOLUSSI, SILVA;ALTIERI, SAVERIO;
2014-01-01

Abstract

BNCT wasproposedforthetreatmentofdiffuse,non-Resectabletumorsinthelung.Weperformedboron biodistribution studies with 5 administration protocols employing the boron carriers BPA and orGB-10 in an experimental model of disseminated lung metastases in rats. All 5 protocols were non-toxic and showed preferential tumor boron uptake versusl ung. Absolute tumor boronconcentrationvalueswere therapeuticallyuseful(25–76ppm)for3protocols.DosimetriccalculationsindicatethatBNCTatRA-3 would bepotentially therapeutic without exceeding radiotolerance in the lung.
2014
Medical Research, Diagnosis & Treatment contains studies of existing and developing diagnostic and therapeutic techniques, as well as specific classes of clinical intervention. Resources in this category emphasize the difference between normal and disease states, with the ultimate goal of more effective diagnosis and intervention. Specific areas of interest include pathology and histochemical analysis of tissue, clinical chemistry and biochemical analysis of medical samples, diagnostic imaging, radiology and radiation, surgical research, anesthesiology and anesthesia, transplantation, artificial tissues, and medical implants. Resources focused on the disease, diagnosis, and treatment of specific organs or physiological systems are excluded and are covered in the Medical Research: Organs & Systems category.
APPLIED RADIATION AND ISOTOPES
sì
WOS:000338606100022
2-s2.0-84901828085
Esperti anonimi
Inglese
Internazionale
STAMPA
88
94
98
5
24360862
BNCT; BPA; GB10; LUNG METASTASES
13
info:eu-repo/semantics/article
262
V. A., Trivillin; M. A., Garabalino; L. L., Colombo; S. J., González; R. O., Farías; A., Monti Hughes; E. C. C., Pozzi; Bortolussi, Silva; Altieri, Sa...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/843647
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