The complexity of pathogenesis in PMF is indicated by the overwhelming greater number of mutation abnormalities other than JAK2 V617F and MPL W515 (Vainchenker et al, 2011); it is therefore intuitive that genetic processes leading to leukaemia in PMF may also differ from those in PV and ET. These reasoning may help to explain why in this study we failed to confirm a leukaemia-predisposing role of the CC ERCC2 polymorphism as reported in PV and ET.
The ERCC2 Gln/Gln polymorphism at codon 751 is not associated with leukaemic transformation in primary myelofibrosis
CAZZOLA, MARIO;
2013-01-01
Abstract
The complexity of pathogenesis in PMF is indicated by the overwhelming greater number of mutation abnormalities other than JAK2 V617F and MPL W515 (Vainchenker et al, 2011); it is therefore intuitive that genetic processes leading to leukaemia in PMF may also differ from those in PV and ET. These reasoning may help to explain why in this study we failed to confirm a leukaemia-predisposing role of the CC ERCC2 polymorphism as reported in PV and ET.File in questo prodotto:
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