The findings of this study indicate that the MYD88 (L265P) mutation is an independent predictor of progression of IgM-MGUS to WM or to other LPD, irrespective of the concentration of the M protein. The presence of both MYD88 mutation and a serum M protein >1.5 g/dL at diagnosis identifies a subset of IgM-MGUS patients at high risk of progression.
MYD88 (L265P) mutation is an independent risk factor for progression in patients with IgM monoclonal gammopathy of undetermined significance
ARCAINI, LUCA;PAULLI, MARCO;CAZZOLA, MARIO
2013-01-01
Abstract
The findings of this study indicate that the MYD88 (L265P) mutation is an independent predictor of progression of IgM-MGUS to WM or to other LPD, irrespective of the concentration of the M protein. The presence of both MYD88 mutation and a serum M protein >1.5 g/dL at diagnosis identifies a subset of IgM-MGUS patients at high risk of progression.File in questo prodotto:
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