A biomimetic sensor based on molecularly imprinted polymer (MIP) and surface plasmon resonance (SPR) transduction, in connection with tapered plastic optical fiber (POF), has been developed for the marker-free, direct and selective detection of low molecular weight substances. The device has been experimentally tested for l-nicotine ((−)-1-methyl-2-(3-pyridyl)pyrrolidine, MW = 162.24). The sensor system developed made the selective and fast detection of l-nicotine possible, with a low cost, easy to realize and small sample volume procedure. The sensor can discriminate between l- and d-nicotine. The linearity range was from 0 to 10^−3M, and the sensitivity strongly depended on the characteristics of thetapered fiber, ranging from 1.3 × 10^4nm/M, for a taper ratio 1.8, to 1.7 × 10^3nm/M for a taper ratio 1, i.e.a not-tapered fiber.

High selectivity and sensitivity sensor based on MIP and SPR in tapered plastic optical fibers for the detection of l-nicotine

D'AGOSTINO, GIROLAMO;PESAVENTO, MARIA;
2014-01-01

Abstract

A biomimetic sensor based on molecularly imprinted polymer (MIP) and surface plasmon resonance (SPR) transduction, in connection with tapered plastic optical fiber (POF), has been developed for the marker-free, direct and selective detection of low molecular weight substances. The device has been experimentally tested for l-nicotine ((−)-1-methyl-2-(3-pyridyl)pyrrolidine, MW = 162.24). The sensor system developed made the selective and fast detection of l-nicotine possible, with a low cost, easy to realize and small sample volume procedure. The sensor can discriminate between l- and d-nicotine. The linearity range was from 0 to 10^−3M, and the sensitivity strongly depended on the characteristics of thetapered fiber, ranging from 1.3 × 10^4nm/M, for a taper ratio 1.8, to 1.7 × 10^3nm/M for a taper ratio 1, i.e.a not-tapered fiber.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/850443
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