Aryl ethynyl anthraquinones have been synthesized by Sonogashira cross-coupling and evaluated as telomeric G-quadruplex ligands, by the FRET melting assay, circular dichroism, the DNA synthesis arrest assay and molecular docking. Both the binding properties and G-quadruplex vs. duplex selectivity are controlled by the structures of the aryl ethynyl moieties

Aryl ethynyl anthraquinones: a useful platform for targeting telomeric G-quadruplex structures

PERCIVALLE, CLAUDIA;MARIANI, ANGELICA;FRECCERO, MAURO
2014

Abstract

Aryl ethynyl anthraquinones have been synthesized by Sonogashira cross-coupling and evaluated as telomeric G-quadruplex ligands, by the FRET melting assay, circular dichroism, the DNA synthesis arrest assay and molecular docking. Both the binding properties and G-quadruplex vs. duplex selectivity are controlled by the structures of the aryl ethynyl moieties
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11571/986078
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